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Objective:To investigate the risk factors of cement vascular leakage after vertebral augmentation for osteoporotic vertebral compression fracture (OVCF).Methods:A case-control study was conducted to analyze the clinical data of 217 patients with OVCF undergone vertebral augmentation [percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP)] in First and Second Affiliated Hospital of Kunming Medical University from October 2019 to October 2020. There were 79 males and 138 females, at the age range of 58-88 years [(73.1±6.9)years]. According to the occurrence of bone cement vascular leakage, the patients were divided into vascular leakage group ( n=39) and vascular leakage free group ( n=178). The gender, age, bone mineral density, time from injury to operation, anatomical position of injured vertebrae, degree of vertebral compression, integrity of posterior wall, intravertebral fissure sign, vertebrobasilar venous foramen, surgical approach, surgical method, cement injection period, cement injection speed, cement injection volume and cement injection area were recorded. Univariate analysis was used to detect the correlation of those indices with cement vascular leakage after vertebral augmentation. Multivariate Logistic regression analysis was used to identify the independent risk factors for cement vascular leakage after vertebral augmentation. Results:Univariate analysis showed that there was a correlation of cement vascular leakage after vertebral augmentation with time from injury to operation, degree of vertebral compression, integrity of posterior wall, intravertebral fissure sign, vertebrobasilar venous foramen, surgical method, cement injection period, cement injection speed, cement injection volume and cement injection area (all P<0.05), apart from gender, age, bone mineral density, anatomical position of injured vertebrae or surgical approach (all P>0.05). Multivariate Logistic regression analysis showed intravertebral fissure sign ( OR=7.00, 95% CI 1.57-31.30, P<0.05), vertebrobasilar venous foramen ( OR=7.52, 95% CI 1.94-29.16, P<0.01), PVP ( OR=10.98, 95% CI 2.51-47.94, P<0.01), injection of cement in thinning period ( OR=5.91, 95% CI 1.45-24.15, P<0.05), injection of large volume of cement ( OR=3.60, 95% CI 1.70-7.65, P<0.01) and marginal injection of cement ( OR=24.80, 95% CI 5.28-116.37, P<0.01) were significantly associated with cement vascular leakage after vertebral augmentation for OVCF. Conclusion:Intravertebral fissure sign, vertebrobasilar venous foramen, PVP, injection of cement in thinning period, injection of large volume of cement and marginal injection of cement are independent risk factors for cement vascular leakage after vertebral augmentation for OVCF.
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Objective To explore the changes in serum inflammatory cytokines,plasma homocysteine (Hcy) and hemorheology in patients with diabetic microangiopathy of different severity.Methods A total of 180 T2DM patients admitted to our hospital from January 2013 to July 2015 were selected and randomized into either the no diabetic retinopathy (NDR) group,background diabetic retinopathy (BDR) group or proliferative diabetic retinopathy (PDR) group,each including 60 patients.We compared serum hypersensitive c-reactive protein (hs-CRP),interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) levels,plasma Hcy level,and hemorheological indicators across the three groups.Results Serum hs-CRP,IL-6 and TNF-α levels,plasma Hcy level and hemorheological indicators were all significantly higher in BDR and PDR groups than in NDR group,with statistically significant differences (P ＜ 0.05).Serum hs-CRP,IL-6 and TNF-αt levels,plasma Hcy level and hemorheological indicators were all significantly higher in PDR group than in BDR group,with statistically significant differences (P ＜ 0.05).Conclusion Serum hs-CRP,IL-6 and TNF-α levels,plasma Hcy level and hemorheological indicators would raise constantly with disease progression in diabetic patients,which might be associated with the development and progression of retinopathy.
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Objective To explore the impact of levocarnitine on microinflammatory state in hemodialysis patients with diabetic nephropathy(DN) .Methods Sixty outpatients and inpatients with DN in the Second Aid Hospital of Xinjiang Uygur Autonomous Region from January 2010 to December 2012 were selected as the research subjects according to the inclusion and exclusion stand‐ards and randomly divided into DN conventional treatment group (conventional treatment group ,n=30) and levocarnitine treatment observation group (levocarnitine treatment group ,n=30) .Contemporaneous 20 individuals undergoing the healthy physical exami‐nation were selected as the healthy control group ,DN was excluded .The two treatment groups were given the insulin therapy ,on the basis of the routine therapy the levocarnitine treatment group was added with levocarnitine oral solution (2 g daily) .The treat‐ment in both groups lasted for 3 weeks .The efficacy was observed and the indicators were detected before and after treatment ,in‐cluding interleukin‐6 (IL‐6) ,C‐reactive protein (CRP) ,tumor necrosis factor‐α(TNF‐α) ,urinary albumin excretion rate (UAER) , serum albumin (Alb) ,hemoglobin (Hb) ,endogenous creatinine clearance rate (Scr) ,total cholesterol (TG) and triglycerides (TC) .The above indicators in the healthy control group were detected in physical examination .Results The CRP ,IL‐6 ,TNF‐αlev‐els after treatment in the conventional treatment group and levocarnitine treatment group were higher than those in the healthy con‐trol group .The CRP ,IL‐6 and TNF‐αlevels after treatment in the levocarnitine treatment group were lower than those in the con‐ventional treatment group .The above 3 inflammatory cytokines levels after treatment in the levocarnitine treatment group were low‐er than before treatment .The TC ,TG and Ccr levels after treatment in the levocarnitine treatment group were lower than those in the conventional treatment group ,while the Alb and Hb levels were higher than those in the conventional treatment group ,the differences were statistically significant (P<0 .05) .Conclusion The microinflammation level after levocarnitine treatment in main‐tenance dialysis patients with DN is alleviated to some extent ,the renal function and nutritional status have certain improvement .
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Objective To investigate the efficiency of radiofrequency ablation (RFA) and microwave ablation (MWA) in treating uterine leiomyoma.Methods The clinical data of thermal ablation with RFA and MWA were retrospectively analyzed in 42 patients.All patients were followed up at least 12 months to observe the therapeutic effects after the treatment.The changes of vital signs and the size of uterine leiomyoma,the score of uterine leiomyoma symptom and quality of Iife(UFS-QOL) were compared after RFA or MWA,the two thermal ablations techniques of clinic efficiency and influence on complications were analyzed.Results 23 patients received treatment of RFA and 19 patients received MWA,the visual analogue scale(VAS)during operation and postoperation were statistically significant differences between the two groups(P ＜0.05).The sizes of uterine leiomyoma were significantly reduced after the thermal ablation,the differences of volume within two groups in different time were statistics significance(P ＜0.05),but there were no statistics significance differences between two groups (P ＞0.05).The symptoms in two groups were improved significantly after treatment and the scores of UFS-QOL were no statistics significance differences between two groups (P ＞0.05).Conclusions Both of RFA and MWA have significant clinic efficiency in treating uterine leiomyoma.Compared with MWA,RFA with lower adverse reactions during operation and postoperation.
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10.3969/j.issn.1007-3969.2013.04.007
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Objective To study the behavioral changes of the spinal cord injury model to provide important data for neuroal factor therapy of the impaired spinal cord.Methods In SD rat,aged 8 weeks,(T7~T8 spinous processes as control),after the spinous process and corresponding lamina of vertebra were removed,the spinal cord was cut by using scissors to prepare the complete transversal abruptly spinal model.The behavioral score of the rat was recorded at different time.The evaluation was made in imageology and pathology.Results The score of SD rat in the experiment group was higher than the control group at different control time.The pathobiology and imageology alterations were very apparent in the damaged spinal area.Conclusion GAP-43 has neuroprotective effect on the recovery of spinal cord injury.